Comparative Bioavailability and Efficasy of Tobra(R) or Tobrex(R).

Kim, Eung Kweon; Kim, Hong Bok; Kim, Sahng Yeon

Original Article

Journal of the Korean Ophthalmological Society 1989;30(2):175-180.
Published online February 1, 1989.

Comparative Bioavailability and Efficasy of Tobra(R) or Tobrex(R).

Eung Kweon Kim, Hong Bok Kim, Sahng Yeon Kim

Department of Ophthalmology, Yonsei University, College of Medicine, Seoul, Korea.

토브라(R) 혹은 Tobrex(R) 점안 후 각막의 tobramycin 농도 및 독성에 관한 비교 연구

김홍복(Hong Bok Kim),김응권(Eung Kweon Kim),김상연(Sahng Yeon Kim)

Abstract

Two topical 0.3% tobramycin ophthalmic solutions, Tobra(R) and Tobrex(R) were tested for their effects on external eyes in rabbits. The authors studied irritation, epithelial toxicity, pH of solutions and antibiotic pharmacokinetics of two kinds of topical tobramycin solutions. No irritation sings were noted after instillation of the two agents with one hour interval. A rabbit epithelial wound healing model demonstrated slight toxicity, but no substantial difference was noted between Tobra(R) and Tobrex(R). In the case of normal corneal epithelia, more than 1 microgram of tobramycin was detectable per gram of cornea 5 minutes after cessation of topical application with both eye drops. In the case of ulcers, the concentrations of tobramycin in the corneae were significantly high with topical route with both eye drops.

Key Words: Tobra(R);Tobrex(R);bioavailability;efficasy