Association between Dry Eye Questionnaires and Dry Eye Sign in Meibomian Gland Dysfunction.

Kim, Jin A; Lee, Si Hyung

doi:2020.61.2.138

J Korean Ophthalmol Soc > Volume 61(2); 2020 > Article

Original Article

Journal of the Korean Ophthalmological Society 2020;61(2):138-145.
DOI: https://doi.org/10.3341/jkos.2020.61.2.138 Published online February 15, 2020.

Association between Dry Eye Questionnaires and Dry Eye Sign in Meibomian Gland Dysfunction.

Jin A Kim, Si Hyung Lee

Department of Ophthalmology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea. sieh12@schmc.ac.kr

마이봄샘 기능이상에서 두 가지 안구건조증 설문지와 안구건조증 지표와의 연관성

김진아 · 이시형

순천향대학교 의과대학 부천병원 안과학교실

Correspondence: Si Hyung Lee,
Email: sieh12@schmc.ac.kr

Received: 2 August 2019 • Revised: 19 September 2019 • Accepted: 22 January 2020

Abstract

PURPOSE
The Ocular Surface Disease Index (OSDI) and the Standardized Patient Evaluation of Eye Dryness (SPEED) which are standard questionnaires of dry eye syndrome were used to determine the associations between clinical dry eye tests and meibomian gland dysfunctions (MGD). METHODS: Forty-one patients with MGD were enrolled in this study. The score of the dry eye syndrome questionnaire and the degree of blepharitis (score: 0–4), Schirmer test results, degree of fluorescence staining of cornea (Oxford Grading System), tear break-up time (TBUT), Pentacam imaging, and anterior segment optical coherence tomography results were used to compare and analyze the results of each test for possible correlations with the dry eye questionnaire answers. RESULTS: There was a significant correlation between OSDI and SPEED (R = 0.278, p = 0.011). SPEED was correlated with the Oxford grade (R = 0.478, p < 0.001) and MGD grade (R = 0.280, p = 0.011) while there was no significant correlation with corneal aberrations, tear meniscus height, tear meniscus area, Schirmer test results, or TBUT. The OSDI correlated with the MGD grade (R = 0.651, p < 0.001), TBUT (R = −0.360, p = 0.001), and age (R = −0.230, p = 0.037). Using multiple regression analyses, the MGD grade affected the OSDI (β = 0.580, p < 0.001) and the Oxford grade significantly influenced the SPEED (β = 0.447, p < 0.001). CONCLUSIONS: In Koreans, the OSDI questionnaire answers were associated with the MGD grade and SPEED questionnaire answers were associated with the corneal surface status. The OSDI questionnaire was therefore clinically useful in patients with meibomian gland dysfunction.

Key Words: Dry eye disease;Meibomian gland dysfunction