Effect of 3% Diquafosol Tetrasodium on Tear Film Stability after Laser-assisted in situ Keratomileusis.

Kim, Chang Hwan; Seong, San; Kim, Jong Ku; Choi, Jae Ho; Choe, Chul Myong; Choi, Tae Hoon; Kim, Sekyung

doi:2019.60.10.915

J Korean Ophthalmol Soc > Volume 60(10); 2019 > Article

Original Article

Journal of the Korean Ophthalmological Society 2019;60(10):915-921.
DOI: https://doi.org/10.3341/jkos.2019.60.10.915 Published online October 15, 2019.

Effect of 3% Diquafosol Tetrasodium on Tear Film Stability after Laser-assisted in situ Keratomileusis.

Chang Hwan Kim, San Seong, Jong Ku Kim, Jae Ho Choi, Chul Myong Choe, Tae Hoon Choi, Sekyung Kim

¹Nune Eye Hospital, Seoul, Korea. sekyungkim@naver.com
²Nune Eye Hospital, Daegu, Korea.

라식수술 후 3% 디쿠아포솔나트륨 사용이 눈물막 안정성에 미치는 효과

김창환¹ · 성 산¹ · 김종구² · 최재호² · 최철명¹ · 최태훈¹ · 김세경¹

서울 누네안과병원¹, 대구 누네안과병원²

Correspondence: Se Kyung Kim, MD
Email: sekyungkim@naver.com

Received: 4 April 2019 • Revised: 27 May 2019 • Accepted: 24 September 2019

Abstract

PURPOSE
To evaluate the efficacy of 3% diquafosol tetrasodium (DQ) after laser-assisted in-situ keratomileusis (LASIK). METHODS: This prospective randomized study included 150 eyes in 75 patients who were scheduled for LASIK. The patients in the 3% diquafosol tetrasodium (DQ) group (37 patients, 74 eyes) were instructed to apply one drop of DQ, six times daily post-op, while the patients in the 0.3% sodium hyaluronate (HA) group (38 patients, 76 eyes) were instructed to apply one drop of HA, six times daily post-op. A Schirmer test, tear film break-up time (BUT), corneal and conjunctival fluorescein staining score (FLSS), and ocular surface disease index (OSDI) were evaluated pre-op and at 1, 4, and 12 weeks post-op while the tear osmolarity was evaluated pre-op and at 4 and 12 weeks post-op. RESULTS: There was no significant difference between the two groups regarding Schirmer test results or tear osmolarity and conjunctival FLSS. The BUT was significantly higher in the DQ group at 1 week and 12 weeks post-op. The corneal FLSS was significantly lower in the DQ group at 1 week, 4 weeks and 12 weeks post-op. The OSDI was significantly lower in the DQ group at 1 week post-op. CONCLUSIONS: Use of 3% diquafosol tetrasodium after surgery improved ocular dryness and increased the tear film stability.

Key Words: Diquafosol;Dry eyes;Laser-assisted in-situ keratomileusis;Tear film stability