| The Efficacy of Vaccinium Uliginosum for Early Age-Related Macula Degeneration. |
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Hyun Kyung Kil, You Mi Song, Koi Chun |
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Department of Ophthalmology, Daejin Medical Hospital, Seongnam, Korea. hk9111@dmc.or.kr |
| 초기 황반변성 환자에서 들쭉 추출물의 효과 |
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길현경⋅송유미⋅전고이 |
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Department of Ophthalmology, Daejin Medical Hospital, Seongnam, Korea |
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| Abstract |
PURPOSE
To evaluate the effect of Bog Bilberry (Vaccinium uliginosum) extract in eyes with early age-related macular degeneration (AMD). METHODS: Forty-four eyes of forty four patients with early AMD were included in this randomized, double-blinded, and placebo-controlled study. All participants were randomly assigned to either the placebo group (n = 24), or the bog bilberry extract group (n = 20). Before drug administration, an ophthalmic examination which included slit lamp microscopy, best corrected visual acuity, and intraocular pressure was performed, and repeated 1and 3 months after treatment. Objective scatter index, glare and tear film break-up time were checked by Optical Quality Analysis System (OQAS, Visiometrics, Spain) and drusen volume, central macular thickness, and RPE and IS/OS junction thickness were investigated with spectral-domain optical coherence tomography (Spectralis, Heidelberg, Germany). RESULTS: In the bog bilberry extract group, RPE and IS/OS junction thickness was significantly increased compared to the placebo group after 3 months of drug administration. CONCLUSIONS: Bog Bilberry extract may play a favorable role in preventing the atrophic change of RPE and IS/OS junction layer and the progression of early macular degeneration. |
| Key Words:
Age-related macular degeneration;Bog bilberry;IS/OS junction;Optical coherence tomography |
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