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Retinal Ganglion Cell Layer Thicknesses and Visual Functions in Patients with Bilateral Temporal Optic Atrophy
양안 이측 시신경위축환자에서 황반부 망막신경절세포층 두께와 시기능과의 연관성
JKOS 2020 Jan;61(1):92-100
Published online January 15, 2020;  https://doi.org/10.3341/jkos.2020.61.1.92
Copyright © 2020 The Korean Ophthalmological Society.
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Bum Gi Kim, MD, Jae Yong Park, MD, Won Hyuk Oh, MD, Jin Choi, MD, PhD
김범기 · 박재용 · 오원혁 · 최 진

Department of Ophthalmology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea
인제대학교 의과대학 상계백병원 안과학교실
Received March 7, 2019; Revised April 29, 2019; Accepted December 30, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Purpose: To investigate correlations between macular retinal ganglion cell (RGC) layer thickness and best-corrected visual acuity (BCVA) and visual field parameters in patients with bilateral temporal optic atrophy.
Methods: Thirty eyes of 15 patients with bilateral temporal optic atrophy and 30 eyes of 15 normal subjects that were age- and sex-matched were included in the study. We measured the thicknesses of the RGC layers of posterior poles using optical coherence tomography volume scanning. The RGC layer was divided into nine zones based on the Early Treatment of Diabetic Retinopathy Study baseline. Possible correlations of the RGC layer with the BCVA and visual field parameters were determined.
Results: The RGC layer thickness was significantly thinner in all patients compared to those in the control group (p = 0.001). The RGC layer thicknesses in the inner superior, inner temporal, inner inferior, and inner nasal areas were significantly correlated with the BCVA (r = -0.650, r = -0.626, r = -0.616, and r = -0.636, respectively; p = 0.000). The RGC layer thicknesses in the outer superior, outer temporal, outer inferior, and outer nasal areas were significantly correlated with the mean deviation of the visual field test (r = 0.470, r = 0.349, r = 0.496, and r = 0.469, respectively; p < 0.05).
Conclusions: In patients with bilateral temporal optic atrophy, the RGC layer thickness in the medial region was correlated with the BCVA, and the RGC layer thickness in the lateral region was correlated with the mean deviation of the visual field test.
Keywords : Optic atrophy, Retinal ganglion cell layer, Visual acuity, Visual disorder, Visual field

 

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