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Clinical Aspects of Phlyctenular Keratoconjunctivitis Using a Tear Film Interferometer
플릭텐각결막염환자의 눈물간섭계를 이용한 임상양상 분석
JKOS 2020 Jan;61(1):1-8
Published online January 15, 2020;
Copyright © 2020 The Korean Ophthalmological Society.
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Dong Hyun Kang, MD, Sang Wroul Song, MD, Byung Yeop Kim, MD, Kyu Yeon Hwang, MD, Kook Young Kim, MD
강동현 · 송상률 · 김병엽 · 황규연 · 김국영

Myung-Gok Eye Research Institute, Department of Ophthalmology, Kim’s Eye Hospital, Konyang University College of Medicine, Seoul, Korea
건양대학교 의과대학 김안과병원 안과학교실 명곡안연구소
Received July 19, 2019; Revised August 16, 2019; Accepted December 30, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Purpose: To evaluate clinical findings in phlyctenular keratoconjunctivitis patients and assess the function and morphology of Meibomian glands using an interferometer (LipiView®, TearScience, Morrisville, NC, USA) in such patients.
Methods: This retrospective study included 19 eyes of 13 patients diagnosed with phlyctenular keratoconjunctivitis. The lipid layer thickness (LLT) and meibograph of each eye was quantified by tear interferometry. Tear film break-up time (TBUT) and corneal staining score were measured. Meibomian gland morphology (lid margin vascularity, plugging of gland orifices, lid margin irregularity, lid margin thickening, and partial glands) was evaluated based on anterior photographs and meibographs.
Results: The mean age was 21.3 years (8-44 years). Mean BUT and Oxford corneal staining scores were 2.6 ± 1.2 seconds and 1.9 ± 0.8, respectively. Abnormal findings of the Meibomian glands were observed in all patients. The mean LLT was 79.6 ± 27.4 µm and the incomplete eye blinking frequency was 3.8 ± 5.9 during 20 seconds. The graphs of the tear lipid layer showed various patterns such as flat, up-hill, down-hill, and mixed.
Conclusions: Meibomian gland dysfunctions and changes in the tear film lipid layer were noted in patients with phlyctenular keratoconjunctivitis. These factors are to be considered for the treatment of phlyctenular keratoconjunctivitis in young patients under 10 years of age.
Keywords : Dry eye, Lipid layer thickness, Meibomian gland, Phlyctenular keratitis, Tear film stability


February 2020, 61 (2)