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Effectiveness of Cyclosporine-steroid Treatment after Cataract Surgery according to Dry Eye Severity
건성안의 정도에 따른 백내장수술 후 싸이클로스포린과 스테로이드 점안액의 병합 치료 효과
JKOS 2019 Sep;60(9):821-8
Published online September 15, 2019;  https://doi.org/10.3341/jkos.2019.60.9.821
Copyright © 2019 The Korean Ophthalmological Society.
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Jae Yeong Park, MD1, Sang Cheol Yang, MD1, Young Min Park, MD, PhD2, Ji Eun Lee, MD, PhD3, Choul Yong Park, MD, PhD4, Jong Soo Lee, MD, PhD1
박재영1 · 양상철1 · 박영민2 · 이지은3 · 박철용4 · 이종수1

Department of Ophthalmology, Pusan National University Hospital, Pusan National University School of Medicine1, Busan, Korea
Department of Ophthalmology, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine2, Changwon, Korea
Department of Ophthalmology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine3, Yangsan, Korea
Department of Ophthalmology, Dongguk University Ilsan Hospital, Dongguk University College of Medicine4, Goyang, Korea
부산대학교 의학전문대학원 부산대학교병원 안과학교실1, 경상대학교 의학전문대학원 창원경상대학교병원 안과학교실2, 부산대학교 의학전문대학원 양산부산대학교병원 안과학교실3, 동국대학교 의과대학 동국대학교 일산병원 안과학교실4
Received February 7, 2019; Revised March 5, 2019; Accepted August 16, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Purpose: To evaluate the effectiveness of topically administered 0.05% cyclosporine combined with a topical steroid in the early postoperative period after cataract surgery, and to compare the therapeutic efficacy according to the severity of dry eye.
Methods: One hundred and fifty-six patients who underwent unilateral cataract surgery and received topical cyclosporine 0.05% for 8 weeks combined with a fluorometholone 0.1% steroid for 4-weeks were classified into three groups according to preoperative dry eye level: the control group, non-dry eye (n = 78); group 1, level I dry eye (n = 38); and group 2, level II dry eye (n = 40). The best-corrected distance visual acuity, intraocular pressure, dry eye symptom questionnaire (ocular surface disease index), tear film break-up time (TBUT), and Schirmer test-I (STI) were evaluated.
Results: The preoperative score of dry eye symptoms improved significantly at one week postoperatively and continued to improve until postoperative 8-weeks in all groups, especially in group 2 compared with the control. Groups 1 and 2 showed significant improvement in the TBUT at one week, four weeks, and eight weeks postoperatively, compared to eight weeks postoperatively in the control; Group 2, especially, showed significant improvement in TBUT. There was no difference in STI value after cyclosporine-steroid treatment in the control group; however, a significant difference was observed at four weeks postoperatively in dry eyes. No significant differences in STI results were observed among the three groups.
Conclusions: Use of topical cyclosporine 0.05% combined with a topical fluorometholone 0.1% steroid after cataract surgery is more effective in dry eyes level II than in non-dry eyes, especially those with TBUT and dry eye symptoms at eight weeks postoperatively.
Keywords : Cataract surgery, Cyclosporine, Dry eye syndrome

 

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