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Choroidal Neovascularization in a Patient with Best Disease
베스트병환자에서 발생한 맥락막신생혈관
JKOS 2019 Aug;60(8):808-15
Published online August 15, 2019;
Copyright © 2019 The Korean Ophthalmological Society.
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Jae Uk Jung, MD, Yu Min Kim, MD, Yong Koo Kang, MD, Dong Ho Park, MD, PhD, Jae Pil Shin, MD, PhD
정재욱 · 김유민 · 강용구 · 박동호 · 신재필

Department of Ophthalmology, Kyungpook National University School of Medicin, Daegu, Korea
경북대학교 의과대학 안과학교실
Received December 27, 2018; Revised February 7, 2019; Accepted July 18, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Purpose: To report a case of choroidal neovascularization in a Best disease patient treated with intravitreal bevacizumab injection and followed up with optical coherence tomography angiography (OCTA).
Case summary: A 20-year-old female visited our clinic with decreased visual acuity of the left eye for 6 months. On optical coherence tomography (OCT), subretinal fluid and hyperreflective subretinal clumps were observed in the macula of the right eye. Subretinal hemorrhage and subretinal fluid were observed in the left eye. Choroidal neovascularization in the left eye was observed using OCTA, fluorescein angiography, and indocyanine green angiography. A full-field electroretinogram was normal in both eyes, but an electrooculogram revealed that the Arden ratio was 1.564 in the right eye and 1.081 in the left eye. Intravitreal bevacizumab injection was performed in the left eye. At 6 months after the intravitreal injection, the best-corrected visual acuity of the left eye had recovered to 20/20. OCT revealed that subretinal fluid reduced and choroidal neovascularization was stable. After 12 months, visual acuity of the left eye was maintained at 20/20, but OCTA revealed that choroidal neovascularization had increased.
Conclusions: Choroidal neovascularization associated with Best disease can improve by intravitreal bevacizumab injection, and the changes in choroidal neovascularization can be followed using OCTA.
Keywords : Bevacizumab, Best disease, Choroidal neovascularization, Optical coherence tomography angiography


December 2019, 60 (12)