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Thyroid Abnormality and Dry Eye Syndrome: a Cross-sectional Study from the Republic of Korea
갑상선 이상과 건성안의 관계: 제5기 국민건강영양조사 자료
JKOS 2019 Aug;60(8):725-30
Published online August 15, 2019;  https://doi.org/10.3341/jkos.2019.60.8.725
Copyright © 2019 The Korean Ophthalmological Society.
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Yeseul Kim, MD1, Jin Kwon Chung, MD2, Si Hyung Lee, MD1
김예슬1 · 정진권2 · 이시형1

Department of Ophthalmology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine1, Bucheon, Korea
Department of Ophthalmology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine2, Seoul, Korea
순천향대학교 의과대학 부천병원 안과학교실1, 순천향대학교 의과대학 서울병원 안과학교실2
Received January 31, 2019; Revised April 11, 2019; Accepted July 18, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Purpose: To investigate the relationship between thyroid abnormality and dry eye syndrome (DES) in a nationally representative Korean population.
Methods: A population-based prospective cross-sectional study was conducted, using the thyroid abnormality data set of the Korean National Health and Nutrition Examination Survey, 2010 - 2012. A total of 16,966 Korean participants with DES were enrolled in the study.
Results: The DES patients were predominantly women, non-smokers and non-drinkers, living in urban regions, with a low income and body mass index (BMI), and with a higher percentage of hypertension, hyperlipidemia, thyroid abnormalities, thyroid diseases, and thyroid cancers. After adjusting for all significant variables, thyroid abnormality (odds ratio [OR], 1.93; 95% confidence interval [CI], 1.43-2.61), thyroid disease (OR, 1.85; 95% CI, 1.37-2.52), and thyroid cancer (OR, 2.45; 95% CI, 1.06-5.67) were significantly associated with DES. There was also a significant association between DES and thyroid abnormalities (OR, 2.02; 95% CI, 1.47-2.76), thyroid diseases (OR, 1.93; 95% CI, 1.41-2.65), and thyroid cancer (OR, 2.62; 95% CI, 1.06-6.62) in the female group, but there was no significant association in the male group.
Conclusions: Thyroid abnormalities, thyroid diseases, and thyroid cancers were associated with DES in a nationally representative Korean population. Close evaluation of thyroid abnormalities is therefore needed when treating female patients.
Keywords : Dry eye syndrome, Thyroid cancer, Thyroid disease

 

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