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Effect and Prognostic Factors of Systemic Steroid Treatment for Strabismus Associated Thyroid Ophthalmopathy
스테로이드 전신투여가 갑상샘눈병증 연관 사시 예후에 미치는 영향 분석
JKOS 2019 Jun;60(6):575-81
Published online June 15, 2019;
Copyright © 2019 The Korean Ophthalmological Society.
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Gwang Rae Shin, MD1, Dae Hyun Kim, MD, PhD2

Barun Eye Clinic1, Gwangju, Korea
Department of Ophthalmology, Chosun University School of Medicine2, Gwangju, Korea
바른안과의원1, 조선대학교 의과대학 안과학교실2
Received January 10, 2019; Revised February 28, 2019; Accepted May 17, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Purpose: To investigate the effect of steroid treatment on strabismus associated with thyroid ophthalmopathy.
Methods: The present retrospective study was conducted on 22 patients diagnosed with strabismus associated with thyroid ophthalmopathy, who were treated with steroids orally or intravenously and followed up for more than one year. Patients were divided into three groups for analysis: an improved group, with no strabismus at the final follow-up visit; a stable group, with no change in the strabismus angle; and a deteriorated group, in which the strabismus angle had worsened. We investigated the characteristics of each group.
Results: In the gender/sex distribution of the 22 patients, 11 of the 15 patients in the improved or stable group were female; six of seven patients in the deteriorated group were male (p = 0.012). Two of the 15 patients in the improved or stable group had a smoking history. However, none smoked after the treatment had started. On the other hand, five of seven patients in the deteriorated group had a smoking history and continued to smoke during and after treatment (p = 0.001). No significant between-group differences were observed with respect to age, diplopia period, strabismus angle, or thyroid function level.
Conclusions: Treatment with steroids may improve or stabilize strabismus associated with thyroid ophthalmopathy. However, the effect of treatment may differ, depending on whether the patient continues to smoke after treatment is initiated.
Keywords : Steroid treatment, Strabismus, Thyroid ophthalmopathy


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